A clinical study was made on 21 cases of malignant germ cell tumors treated at the Department of Obstetrics and Gyneclogy in Yengnam University Hospital between May 1983 and April 1992.
@ES The results obtained were as follows:
@EN 1. The frequency of malignant germ cell tumor among 96 cases of ovarian cancer in this period was 21.9%, By the histologic type, the endodermal sinus tumor was 7 cases(33.35), dysgerminoma was 6 cases(28.6%), immature teratoma was 6
cases(28.6%),
embryonal carcinoma was 1 case(4.8%) and adenocarcinoma arising in the benign cystic teratoma was 1 case(4.8%).
2. The mean age of the patients at presentation was 22.7% years(10~73 years).
3. The mean tumor diameter was 14.1cm(10~30cm).
4. No site predilection of development of malignant germ cell tumor was identified in this study : right side in 9 cases(42.9%), left side in 9 cases(42.9%), and bilateral tumor in 3 cases(14.3%).
5. Main clinical symptoms were abdominal pain/discomfort(47.6%), abdominal mass (38.1%) and abdominal distention(14.3%) in ordor.
6. Sixty-two percent(13/21) of malignant germ cell tumors was FIGO stage I at the time of initial diagnosis.
7. Eight of twenty-one patients were treated by surgery alone, 10 of 21 patients by surgery and multiple agent combination chemotherapy, 1 of 21 patients by surgery and radiotherapy and 1 of 21 patients by surgery, radiothery and chemotherapy
8. Two of twenty-one patients underwent second look operation after 9 courses of chemother : All patients had shown surgical complete remission and no patients recurred following negative second look operation.
9. Disease-free interval was from 10 months to 50 months in EST and from 39 months to 87 months in dysgerminoma. And overall 2-year survival rate of malignant germ cell tumor was 60%.
10. Prognostic factors of malignant germ cell tumor in this study were the clinical stage, the histologic type and the size of residual tumor mass.
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